Venezuelan President Nicolas Maduro has said that a United States military deployment in the Caribbean is aimed at overthrowing his government, viewed as a longtime foe by the US.

In a series of rare remarks before reporters on Monday, Maduro said that Venezuela seeks peace but that the military is prepared to respond to any attacks from US forces.

“They are seeking a regime change through military threat,” Maduro told journalists. “Venezuela is confronting the biggest threat that has been seen on our continent in the last 100 years.”

Maduro has raised alarm over a US naval buildup in the region, ostensibly for the purpose of combating drug trafficking, that has caused speculation about possible military interference against Venezuela. The Venezuelan leader has deployed troops along the South American nation’s borders and called on citizens to join militias.

The US Navy currently has two Aegis guided-missile destroyers – the USS Gravely and the USS Jason Dunham – in the Caribbean, along with the destroyer USS Sampson and the cruiser USS Lake Erie in the waters off Latin America.

The news agency Associated Press has reported that those forces could expand further in the coming days, with the inclusion of amphibious assault ships with 4,000 sailors and US Marines. The US, for its part, has not announced plans to deploy any personnel to Venezuelan soil.

US President Donald Trump’s administration has accused Maduro of close connections to an array of drug trafficking and criminal organisations throughout the region, claims for which it has thus far failed to offer any evidence.

The US doubled its reward for information leading to Maduro’s arrest over allegations of involvement in drug trafficking to $50m in August.

In May, US media reported that an internal intelligence memo concluded that there was no evidence linking Maduro to the Venezuelan criminal group Tren de Aragua, undercutting a claim pushed publicly by Trump and his allies. That allegation had also been an important component of the administration’s push to rapidly deport Venezuelans accused of membership without due process.

Despite his frequent use of rhetoric railing against the history of US intervention in Latin America, the Venezuelan leader had previously expressed an interest in cooperating with the Trump administration in areas such as immigration enforcement, agreeing to accept Venezuelans deported from the US.

During his press conference on Monday, Maduro also insisted that he was the rightful ruler of the country after winning a third term in a strongly contested 2024 election. The opposition has maintained that they were the true winners of that election, and neither the US nor most regional governments have recognised Maduro’s victory.